Fig. 1

Phosphatidylserine (PS) exposure on platelets. Isolated platelets were incubated with Alexa Fluro 488-lactadherin separately in the dark for 10 min at room temperature before flow cytometric analysis. A representative set of histograms is shown to illustrate lactadherin-positive (PS⁺) platelets from (a) one stage II patient with colon cancer, and (b) one stage IV patient. c Comparison of PS⁺ platelets among healthy subjects (n = 33), and colon cancer patients in different stage (stage I: n = 16, II: n = 47, III: n = 28, or IV: n = 21). Data displayed are mean ± SD. ***P <0.001