Cell line | MBIC | Colchicine | Nocodazole | Paclitaxel | Doxorubicin | Cisplatin | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 | IC50 | SI | IC50 | SI | IC50 | SI | IC50 | SI | IC50 | SI | IC50 | SI |
IC50 (μM)/24 hours | ||||||||||||
  HeLa | 0.21 ± 0.02 | 48.04 | 3.01 ± 0.03 | 2.66 | 3.08 ± 0.02 | 3.97 | 1.02 ± 0.01 | 6.57 | 0.46 ± 0.04 | 7.73 | 15.07 ± 0.03 | 1.23 |
  HCT-116 | 2.72 ± 0.4 | 3.70 | 5.34 ± 0.2 | 1.50 | 3.81 ± 0.6 | 3.20 | 3.09 ± 0.5 | 2.17 | 0.91 ± 0.2 | 3.91 | 7.22 ± 0.5 | 2.57 |
  A549 | 1.29 ± 0.07 | 7.82 | 7.78 ± 0.3 | 1.03 | 12.16 ± 0.2 | 1.00 | 2.83 ± 0.11 | 2.37 | 0.35 ± 0.07 | 10.17 | 34.04 ± 0.9 | 0.54 |
  HepG-2 | 2.92 ± 0.1 | 3.45 | 8.36 ± 0.9 | 0.95 | 10.71 ± 0.5 | 1.14 | 2.81 ± 0.72 | 2.38 | 8.04 ± 0.8 | 0.44 | 10.31 ± 0.5 | 1.80 |
  WRL-68 | 10.09 ± 1.2 |  | 8.02 ± 0.5 |  | 12.23 ± 0.9 |  | 6.71 ± 0.2 |  | 3.56 ± 0.9 |  | 18.6 ± 1.4 |  |
IC50 (μM)/48 hours | ||||||||||||
  HeLa | 0.19 ± 0.03 | 37.68 | 2.02 ± 0.02 | 2.04 | 2.22 ± 0.04 | 3.40 | 0.57 ± 0.03 | 5.98 | 0.29 ± 0.04 | 5.79 | 9.02 ± 0.02 | 1.17 |
  HCT-116 | 2.01 ± 0.3 | 3.56 | 3.44 ± 0.2 | 1.20 | 1.81 ± 0.3 | 4.17 | 1.09 ± 0.4 | 3.12 | 0.47 ± 0.3 | 3.57 | 4.12 ± 0.6 | 2.56 |
  A549 | 0.53 ± 0.1 | 13.50 | 3.21 ± 0.7 | 1.28 | 5.09 ± 0.5 | 1.48 | 1.23 ± 0.09 | 2.77 | 0.09 ± 0.01 | 18.66 | 19.51 ± 1.4 | 0.54 |
  HepG-2 | 1.03 ± 0.09 | 6.95 | 4.08 ± 0.4 | 1.01 | 5.08 ± 0.3 | 1.48 | 1.03 ± 0.07 | 3.31 | 3.94 ± 0.07 | 0.42 | 5.93 ± 0.2 | 1.78 |
  WRL-68 | 7.16 ± 0.9 |  | 4.14 ± 0.7 |  | 7.56 ± 0.3 |  | 3.41 ± 0.8 |  | 1.68 ± 0.09 |  | 10.56 ± 0.7 |  |