Table 3 Drug sensitivity IC50-values and relative resistances

HCT116-Wt

0.05 ± 0.01

1

0.06 ± 0.03

1

0.17 ± 0.1

1

0.09 ± 0.01

1

6.3 ± 2.8

1

HCT116-SN38

3.4 ± 0.6

67

47 ± 46 ^a

782

47 ± 46

280

0.2 ± 0.03

2.1

4.4 ± 3.5

0.7

HT29-Wt

0.13 ± 0.06

1

0.03 ± 0.01

1

0.07 ± 0.04

1

0.18 ± 0.02

1

9.9 ± 3.7

1

HT29-SN38

7.3 ± 1.7

55

1.2 ± 0.7

36

0.14 ± 0.04

2

2.0 ± 0.9

11

38 ± 17

4

LoVo-Wt

0.02 ± 0.004

1

0.02 ± 0.01

1

0.06 ± 0.02

1

0.11 ± 0.03

1

1.8 ± 1.9

1

LoVo-SN38

0.44 ± 0.2

20

0.09 ± 0.03

4.1

0.05 ± 0.03

0.8

0.95 ± 0.4

9

2.7 ± 1.6

1.5