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Table 3 Drug sensitivity IC50-values and relative resistances

From: Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations

Cell line SN-38 NSC 725776/LMP776 NSC 743400/LMP400 Epirubicin Etoposide
  IC50 RR IC50 RR IC50 RR IC50 RR IC50 RR
HCT116-Wt 0.05 ± 0.01 1 0.06 ± 0.03 1 0.17 ± 0.1 1 0.09 ± 0.01 1 6.3 ± 2.8 1
HCT116-SN38 3.4 ± 0.6 67 47 ± 46 a 782 47 ± 46 280 0.2 ± 0.03 2.1 4.4 ± 3.5 0.7
HT29-Wt 0.13 ± 0.06 1 0.03 ± 0.01 1 0.07 ± 0.04 1 0.18 ± 0.02 1 9.9 ± 3.7 1
HT29-SN38 7.3 ± 1.7 55 1.2 ± 0.7 36 0.14 ± 0.04 2 2.0 ± 0.9 11 38 ± 17 4
LoVo-Wt 0.02 ± 0.004 1 0.02 ± 0.01 1 0.06 ± 0.02 1 0.11 ± 0.03 1 1.8 ± 1.9 1
LoVo-SN38 0.44 ± 0.2 20 0.09 ± 0.03 4.1 0.05 ± 0.03 0.8 0.95 ± 0.4 9 2.7 ± 1.6 1.5
  1. Mean IC50-value (μM) ± standard deviation of three experiments. RR; relative resistance is the IC50-value of the resistant cell line divided by the IC50-value of the parental (wild-type, Wt) cell line
  2. aDid not reach IC50, so the actual IC50-value is larger than this. IC50-values for SN-38 are provided for comparison