Fig. 2

SPAG5 overexpression is associated with PCa progression and poor prognosis. a-d, Box plots showed that SPAG5 was significantly increased in patients with higher Gleason score relative to patients with lower Gleason score; e, Box plots showed that SPAG5 was significantly increased in patients with higher grade relative to patients with lower grade; f, g, Box plots showed that SPAG5 mRNA was significantly overexpressed in dead PCa patients compared with living PCa patients at 3 years and 5 years, respectively; h, i, Box plots showed that SPAG5 mRNA was significantly increased in PCa patients with BCR compared with PCa patients without BCR at 3 years, and 5 years, respectively. j-l, Immunohistochemical analysis of SPAG5 in, less aggressive PCa (j), aggressive PCa (h), and CRPC (l)