Fig. 6

Gain- and loss-of-function study with SH2B1 expression vector and siSH2B1 in cells proliferation in vitro. To investigate whether SH2B1 expression may interfere or mimic the function of miR-361-3p, NSCLC cells were transfected by SH2B1 siRNA or SH2B1 expression vector to inhibit or restore the SH2B1 expression. CCK8 assay (a), colony formation (b). Data were represented as the mean ± SEM of three independent experiments. *P < 0.05, **P < 0.01