Fig. 1
Anti-metastatic efficacy of 1-MNA and 1,4-DMP in the model of experimental metastasis of 4T1-luc2-tdTomato cells. a Luminescence intensity of 4T1-luc2-tdTomato cells visualized during intravital imaging of mice treated with 1-MNA and 1,4-DMP (100 mg/kg/day in a drinking water) from the 7th day prior cancer cells intravenous transplantation. Data are presented as mean values ± SD. b Images of luminescence intensity taken on the 10th day of the experiment for untreated animals (upper row), mice treated with 1-MNA (middle row), mice treated with 1,4-DMP (bottom row). c Kaplan-Meier survival curves obtained for the animals treated with 1-MNA and 1,4-DMP (days of administration are indicated on the graph with an arrow)