Fig. 2

The influence of 1-MNA and 1,4-DMP on the growth, angiogenesis and metastasis of 4T1 tumors. a Tumor growth kinetics in mice treated with 1-MNA or 1,4-DMP given at the dose of 100 mg/kg/day in drinking water from the 7th day of the experiment (administration period is marked on the graph with an arrow). Data are presented as mean values ± SD. b Median number of lung metastases in BALB/c mice bearing 4T1 tumors. Data are presented as raw values with medians. c Wash-in-rate values estimated by the ultrasound imaging of 4T1 tumor blood perfusion performed on the 25th day of the experiment. Data are presented as median values ± min/max. d Representative images of tumor perfusion taken for: (I) control group, (II) mice treated with 1-MNA and (III) mice treated with 1,4-DMP