Fig. 6

Tumors derived from SCC-9/Sam68 cells grew faster than tumors derived from the vector-control and scramble-control cells. Oppositely the SCC-9/Sam68 shRNA cells grew slowly than tumors derived from the vector-control and scramble-control cells. DDP blocked tumor growth with highest sensitivity in tumors derived from SCC-9/Sam68 shRNA cells, but lowest sensitivity in tumors derived from SCC-9/Sam68 cells (a). After 28 days culture, the volumes of tumors formed by SCC-9/Sam68 cells were significantly larger than those of tumors derived from vector-control and scramble-control cells. In contrast, depletion of endogenous Sam68 in SCC-9 cells caused significant inhibition of tumor growth in volume (b)