Fig. 6
From: CD317 Promotes the survival of cancer cells through apoptosis-inducing factor
Proposed role of CD317 in apoptosis. In response to death stimulus, mitochondria swelled, dropt mitochondrial membrane potential (MMP) and aggrandized the permeability, resulting in the release of apoptotic molecules such as cytochrome c and AIF. Cytochrome c initiated caspases processing in cytoplasm and ultimately induced cell apoptosis, while AIF translocated to the nucleus to induce chromatin condensation in a caspase-independent manner. CD317 plays an inhibitory role in the mitochondria-AIF axis, protects cells from nutrient deficient-induced apoptosis