Fig. 4

Histological evaluation of tumor necrosis. a Representative examples of necrotic (black dashed lines) tumor areas are shown for each treatment group. Areas overlaid with a striped pattern were not considered for evaluation (e.g. bone, muscle, absence of tissue). Scale bar corresponds to 500 μm (5X). b Quantitation of tumor necrosis, normalized to the total tumor area which was available for analysis. *p < 0.05 as compared to the indicated treatment