From: Heregulin-1ß and HER3 in hepatocellular carcinoma: status and regulation by insulin
Number | HER3 mRNA fold induction (T/NT)a | P values | Heregulin-1ß fold induction (T/NT)a | P values | |
---|---|---|---|---|---|
HBV | |||||
Yes No | 27 58 | 2.38 [0.29–20.25] 1.55 [0.07–15.51] | 0.033 | 0.02 [0.00–4.56] 0.13 [0.00–25.46] | 0.075 |
HCV | |||||
Yes No | 21 64 | 1.30 [0.25–12.86] 2.21 [0.07–20.25] | 0.016 | 0.06 [0.00–4.17] 0.095 [0.00–25.46] | 0.724 |
NASH | |||||
Yes No | 11 74 | 2.74 [0.69– 5.30] 1.60 [0.07–20.25] | 0.313 | 0.33 [0.02–2.04] 0.05 [0.00–25.46] | 0.074 |
MS + alcohol | |||||
Yes No | 8 77 | 1.32 [0.85–4.50] 2.06 [0.07–20.25] | 0.425 | 0.715 [0.05–25.46] 0.06 [0.00–4.56] | 0.011 |
Alcohol | |||||
Yes No | 5 80 | 2.11 [0.96–6.77] 1.85 [0.07–20.25] | 0.727 | 0.10 [0.00–0.89] 0.08 [0.00–25.46] | 0.783 |
Advanced fibrosis/cirrhosis | |||||
Yes No | 50 35 | 1.52 [0.25–20.25] 2.60 [0.07–15.51] | 0.150 | 0.090 [0.00–4.17] 0.090 [0.00–25.46] | 0.719 |
AFPb | |||||
< 400 ng/ml ≥ 400 ng/ml | 47 34 | 1.85 [0.07–20.25] 2.09 [0.25–15.51] | 0.867 | 0.13 [0.00–4.56] 0.05 [0.00–25.46] | 0.293 |
Tumour size | |||||
< 5 cm ≥ 5 cm | 44 41 | 1.47 [0.25–7.89] 2.68 [0.07–20.25] | 0.019 | 0.09 [0.00–4.56] 0.09 [0.00–25.46] | 0.631 |
Multiplicity | |||||
Yes No | 18 67 | 2.05 [0.32–20.25] 1.94 [0.07–7.89] | 0.796 | 0.24 [0.00–4.17] 0.06 [0.00–25.46] | 0.310 |
Satellite nodules | |||||
Yes No | 26 59 | 2.11 [0.07–20.25] 1.58 [0.25–7.89] | 0.458 | 0.15 [0.00–25.46] 0.05 [0.00–4.56] | 0.164 |
Differentiation | |||||
Well/moderate Poor | 61 24 | 2.22 [0.29–20.25] 1.43 [0.07–6.77] | 0.021 | 0.23 [0.00–25.46] 0.01 [0.00–1.76] | 0.001 |
CK19 expressionc | |||||
< 5 % ≥ 5 % | 65 17 | 1.85 [0.25–20.25] 2.44 [0.07–15.51] | 0.926 | 0.11 [0.00–25.46] 0.01 [0.00–1.06] | 0.006 |
Microvascular invasion | |||||
Yes No | 41 44 | 2.08 [0.07–20.25] 1.56 [0.29–6.94] | 0.194 | 0.08 [0.00–25.46] 0.09 [0.00–4.56] | 0.624 |