Fig. 3

Pulsatile, high dose of sunitinib in vivo results in inhibition of tumor growth and significantly higher plasma and intratumoral sunitinib concentrations compared to the standard, daily schedule. a Photos of HT29 tumors growing on the CAM representative of the three treatment arms (vehicle, 40 mg/kg of sunitinib daily from EDD12 to EDD20 (designated as “daily) or 120 mg/kg twice per week, on EDD12 and EDD20 (designated as “weekly”). b Increase in tumor volume during treatment for the three treatment arms. Error bars, SEM. c Weight (in mg) of the collected tumors, in each treatment arm. d, e Concentration of sunitinib in the plasma and the collected tumors per treatment arm. Error bars, SD.*, p < 0.05, ** p < 0.01, NS: not significant