Fig. 6
From: Heat shock protein 70-2 (HSP70-2) overexpression in breast cancer
HSP70-2 depletion in MDA-MB-231 tumor cells initiates apoptosis and inhibits EMT in tumor xenograft. Representative IHC images show altered expression of apoptotic molecules (BAD, BAX, BID, PUMA, NOXA, Cytochrome-C, Caspase 3, Caspase 6, Caspase 7, Caspase 9, APAF1, AIF, PARP1, BCL2, BCL-xL, MCL1, cIAP2, XIAP, Survivin, GRP78), epithelial (E-Cadherin) and mesenchymal markers (N-Cadherin, P-Cadherin, SLUG, SMA, SNAIL, TWIST, Vimentin, MMP2, MMP3, MMP9) in sections of tumor treated with shRNA4 and NC shRNA. Objective: ×20, Magnification: ×200