Fig. 1

Analysis of TIMP1 RNA expression on the basis of the Oncomine and Cancer Genome Atlas (TCGA) database. a-c Exhibition of TIMP1 expression of normal specimens and colorectal carcinoma from colorectal statistics in Oncomine dataset (a Graudens E, 2006; b Skrzypczak M, 2010; c, Hong Y, 2010). The expression fold changes were 2.169, 5.929 and 5.883 times, respectively, all p < 0.01. d TCGA dataset showed that the TIMP1 level was increased in stages I, II, III, and IV compared with that in adjacent normal mucosa