Fig. 6

HCC cell-derived exosomes reverse sorafenib-induced apoptosis in hepatoma carcinoma cells in vivo. a Tumors from mice treated with PBS (Control), sorafenib (Sora), sorafenib + LO2-exosomes (Sora + LO2 exo), sorafenib + MHCC-97 L-exosomes (Sora + 97 L exo), and sorafenib + MHCC-97H-exosomes (Sora + 97H exo) were paraffin-embedded and sectioned, followed by staining of apoptotic cell by using TUNEL assays. b The number of TUNEL-positive cells notably decreased in the sorafenib + MHCC-97 L-exosome or sorafenib + MHCC-97H exosome groups compared to the those of the sorafenib alone or sorafenib + LO2-exosome groups (* P <0.05)