Fig. 1

Targeting the cell cycle checkpoints in cancer. a Chk1/2 or ATR inhibitors in combination with DNA damaging drugs forces cancer cells with DNA damage to bypass the S and G2/M checkpoint arrest and enter mitosis, leading to cell death. b Wee1 inhibitors in combination with DNA damaging drugs forces cancer cells with DNA damage to bypass the G2/M checkpoint arrest and progress into mitosis, leading to cell death. c Wee1 inhibitors sustain the SAC-dependent mitotic delay induced by AMCDs, substantially increasing AMCDs therapeutic efficacy