Fig. 10
From: LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC
The combination of LCL161 and paclitaxel inhibits cIAP1 and cIAP2 and activates caspase-3 in vivo. a The histology of tumor xenograft tissues was confirmed using hematoxylin and eosin (H&E) staining. cIAP1, cIAP2, Ki67 and activated caspase-3 were detected by immunohistochemistry. Original magnification, ×200. b Quantification of the ratio of the positive staining in each tumor tissue region, provided as mean ± SD; *P < 0.05; **P < 0.01; ***P < 0.001