Fig. 7From: Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexateThe proposed mechanism by which shockwave treatment increases osteosarcoma cell death: Shockwave promote the release of intracellular ATP, which in turn binds P2X7 receptors that contribute to the opening of cell membrane channels that allow entrance of MTX into cells,by which the osteosarcoma cell death increasesBack to article page