Fig. 8

RF-Id inhibits cIAP2 and XIAP activity and NFκB pathway. RF-Id disrupts XIAP-cIAP2 binding by inducing XIAP ubiquitination and proteosome-mediated degradation. Moreover, RF-Id stabilizes c-IAP2 at the protein level but inhibits its activity as caspases inhibitor by blocking BIR3 domain of cIAP2, thus activating caspases 3,7, 8 and 9. Moreover, blockade of cIAP2-XIAP complex formation increases IkBα expression leading to NFκB inactivation and apoptosis induction