Tripartite motif containing 62 is a novel prognostic marker and suppresses tumor metastasis via c-Jun/Slug signaling-mediated epithelial-mesenchymal transition in cervical cancer

Table 1 Correlation between TRIM62 Expression and Clinicopathologic Characteristics of Early-stage CC in Training Cohort and Validation Cohort

Clinicopathologic Variable	Training Cohort				Validation Cohort
	Total	TRIM62 expression		P-value	Total	TRIM62 expression		P-value
		low	High			low	High
Age(years)
≦42	61	40	21	0.388	44	26	18	0.973
> 42	47	27	20		37	22	15
FIGO stage
Ia2	9	2	7	0.063	11	2	9	*0.007* ^a
Ib1	56	34	22		39	22	17
Ib2	18	12	6		14	9	5
IIa1	12	8	4		7	6	1
IIa2	13	11	2		10	9	1
Tumor size(cm)
≦4	74	41	33	*0.036*	54	27	27	*0.016*
> 4	34	26	8		27	21	6
Pathologic types
Squamous cell carcinoma	68	43	25	0.738	53	30	23	0.503
Adenocarcinoma	40	24	16		28	18	10
Differentiation grade
Well	9	4	5	0.081	7	3	4	*0.046* ^a
Moderate	48	26	22		36	17	19
Poor	51	37	14		38	28	10
Stromal invasion
< 1/2	61	30	31	*0.004*	50	25	25	*0.031*
≧1/2	47	36	11		31	23	8
Lymphovascular space invasion
Yes	14	12	2	0.050	11	8	3	0.511^a
No	94	55	39		70	40	30
Pelvic-lymph node metastasis
Yes	18	15	3	*0.041*	14	11	3	0.106
No	90	52	38		67	37	30
Vaginal involvement
Yes	4	4	0	0.295^a	3	3	0	0.267^a
No	104	63	41		78	45	33
Parametrial infiltration
Yes	3	3	0	0.287^a	2	2	0	0.511^a
No	105	64	41		79	46	33
Recurrence
Yes	24	22	2	*0.001*	20	18	2	*0.001*
No	84	45	39		61	30	31
Vital status at follow-up
Alive	86	47	39	*0.002*	61	30	31	*0.001*
Dead	22	20	2		20	18	2

Abbreviations: FIGO the International Federation of Gynecology and Obstetrics
^a P-value from Fisher’s exact test; The bold number inside the table reflected P < 0.05

ISSN: 1756-9966