Fig. 3
From: A panel of four genes accurately differentiates benign from malignant thyroid nodules
Flowchart of the study design. Totally 212 differential expressed genes were identitied by using whole-transcriptome sequencing of 19 paired PTC tissue samples. Only 33 genes were identitied when log2FC > 4 and we only focusd on those 33 over expressed genes. Then we got the intersection of those 33 over expressed genes and adenocarcinoma related genes, including 12 genes. we investigated the expression of these 12 overexpressed genes in our 19 paired PTC samples with sequencing data, 4 genes with the most diagnostic value were picked out (FN1, GABRB2, NGEF and HMGA2). High accuracy of diagnosis was both realized in training set and validation set