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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II

Fig. 7

The molecular docking for the interaction modes of lapachol-TOP I (a) and lapachol-TOP II (b). MOE 2010 software package was used for docking TOP I and II. Crystal structures of TOP I-ligand complex (PDB entry: 1SC7, 3.0 Å) and TOP II-ligand complex (PDB entry: 1ZXM, 1.87 Å) were used. The scores of lapachol-TOP I and lapachol-TOP II were -12.59 and -6.71, respectively

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