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Table 1 The cytotoxicity of B5G9 in HepG2, HepG2/ADM, Hep3B and Bel-7402 hepatoma carcinoma cell lines

From: A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells

Compounds IC50 (μM) (24 h)
HepG2 HepG2/ADM Hep3B Bel-7402
B5G9 3.73 ± 0.25 9.94 ± 0.50 10.00 ± 0.55 13.80 ± 0.65
23-HBA 30.35 ± 2.76 40.67 ± 3.73 39.78 ± 3.56 42.78 ± 4.03
  1. HepG2, HepG2/ADM, Hep3B and Bel-7402 cells were treated with different concentrations of B5G9 and 23-HBA for 24 h. Cell viability was measured by MTT assay and IC50 values were calculated according to the MTT curves