Fig. 2

OL altered expression of genes in NPC cells. a NPC cells HNE-1 and HONE-1 were incubated for 24 h with media containing 0 or 200 μM of OL, respectively, and then subjected to microRNA array analysis. 22 miRNAs upregulated in both HNE-1 and HONE-1 cells were shown. b to c mRNA levels of HIF1α (b), PDRG1 (c), as well as their protein levels (d) were analyzed in both HNE-1 and HONE-1 cells treated as in (a). Values were expressed as mean ± SD. * p < 0.05, ** p < 0.01, compared to 0 μM OL