Fig. 6
From: HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features
NNRTIs are effective to restrain HERV-K activation and induce apoptosis in TVM-A12 CD133+ cells. Effects of NNRTIs on the expansion and maintenance of CD133+ cells in TVM-A12 (a) and TVM-A12-CD133+ (b) cell lines analyzed by flow cytometry analysis. Effects of NNRTIs on apoptosis levels in TVM-A12 (c) and TVM-A12-CD133+ (d) analyzed by flow cytometry analysis after nuclei staining with propidium iodide. Relative mRNA expression of HERV-K env gene (e) and CD133 (f) analyzed by Real-time PCR. Data represent the results of three independent experiments