Fig. 5
Diagram of the putative effects of itraconazole on gastric cancer cells. Itraconazole down-regulates the expression of Gli1 by yet unknown mechanisms and subsequently regulates the expression of several downstream target genes, including p21waf1/cip1, and p27kip1, Bax and PARP, thereby regulating many cellular processes, such as proliferation, survival, cell cycle and apoptosis