Fig. 1
From: Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2
Benz binds to HK2 and inhibits HK2 enzyme activity. a Chemical structure of Benz. b H-bond interactions between Benz and HK2 residues. Benz and substrate glucose are depicted as ball-and-stick model. c Benz occupies the binding site of the substrate glucose d Selectivity enzymatic inhibitory efficacy against HK2 versus HK4 and HK1. e- f The alteration of maximal reaction rate (Vmax) and kinetic constant Km. All data presented were the mean ± SEM of three independent experiments