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Table 1 Relationship between HIF-1α, LOXL2 and the cliniopathological features in hepatocellular carcinoma tissues

From: HIF-1α promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment

Variants HIF-1α χ 2 P-value LOXL2 χ 2 P- value
- + - +
Sex
 male 89 80 0.000 0.989 80 89 1.560 0.212
 female 18 14 19 13
Age (years)
  < 50 35 23 1.656 0.198 32 26 1.143 0.285
  ≥ 50 72 71 67 76
Tumor size (cm)
  < 5 49 32 2.872 0.090 43 38 0.797 0.372
  ≥ 5 58 62 56 64
Grade
 I + II 59 37 4.993 0.025* 55 41 4.750 0.029*
 III + IV 48 57 44 61
Metastasis
 NO 45 33 1.687 0.194 44 34 2.612 0.616
 YES 62 61 55 68
VM
 NO 89 64 6.270 0.012* 82 71 4.830 0.028*
 YES 18 30 17 31
  1. *p <0.05
  2. HIF-1α protein was highly expressed in 94 of 201 HCC sample tissues (46.76%). LOXL2 protein was highly expressed in 102 of 201 HCC sample tissues (50.75%). Elevated HIF-1α and LOXL2 expression was correlated with an increase in tumor grade and VM