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Table 3 Estimated IC50 mean values ± SEM of drugs in primary EOC cell lines transfected with scramble-siRNA and FOXM1-specific siRNA

From: FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients

 

IC50 values ± SEM

EOC-CC1

OSPC2

Drug

siControl

siFOXM1

siControl

siFOXM1

Cisplatin (μM)

1.9 ± 0.2

1.1 ± 0.1

p = 0.008

11 ± 0.4

5 ± 0.5

p < 0.001

Carboplatin (μM)

153 ± 15

57 ± 3

p = 0.003

236 ± 3

173 ± 2

p < 0.001

Doxorubicin (nM)

466 ± 17

119 ± 1

p < 0.001

270 ± 26

190 ± 3

p = 0.006

Olaparib (μM)

330 ± 7

233 ± 13

p = 0.05

101 ± 9

42 ± 2

p = 0.003