Fig. 1

ANGPTL1 mRNA expression is down-regulated in CRC tissues, and its high expression predicts better survival. a Volcano plot of the gene expression data from TCGA. The x-axis denotes the log2 fold change of gene expression in normal relative to tumor tissues (i.e., 5 represents a log2 fold change of 5.0 in normal vs. tumor tissues). Genes represented with blue dots are highly statistically significant with greater than 2-fold changes. The results demonstrated that ANGPTL1, ANGPTL5 and ANGPTL7 were significantly down-regulated in CRC samples. b In the GSE32323 dataset, ANGPTL1 was expressed at low levels in tumor samples (P = 0.01). c Similar reduction in the expression of ANGPTL1 in CRC was also found in patients at our oncology center (P = 0.02). d Patients with high ANGPTL1 expression in TCGA dataset had significantly longer OS than those with low levels of ANGPTL1 expression in stage IV CRC patients (P = 0.03). e In the GSE24550 cohort, high expression of ANGPTL1 predicted better disease-free survival in stage III patients (P = 0.03)