Fig. 1

Serum miR21 was elevated in B-cell lymphoma and indicated lymphoma progression. a Serum miR21 was significantly higher in DLBCL patients than in health volunteers. The relative expression level of each patient was calculated based on the lowest expression value. b A significant correlation was observed between serum and tumor miR21 expression level. Correlation coefficient was determined by Pearson correlation coefficient analysis. c Patients with high serum miR21 expression displayed significantly increased tumor CD31 positivity. The patients with miR21 expression level over and equal to the median value were regarded as high miR21 expression, while those below to the median value were included into the low miR21 expression