Fig. 2

MiR21 overexpression enhanced B-lymphoma cell chemoresistance but ABT-199 sensitivity involving tumor microenvironment. a Cell growth was determined by MTT assay under the monoculture condition of SU-DHL-4 and SU-DHL-8 cells treated with doxorubicin, cisplatin and ABT-199. b Comparing with the control mimics, transfection with miR21 mimics in SU-DHL-4 and SU-DHL-8 cells resulted in significantly increased miR21 expression. MiR21 overexpression induced Bcl-2 expression on SU-DHL-4, but not on SU-DHL-8. c MiR21 overexpression induced lymphoma cell resistance to doxorubicin (50 nm in SU-DHL-4, 55 nm in SU-DHL-8) or cisplatin (5 μM in SU-DHL-4, 7 μM in SU-DHL-8) in the monoculture system and in the co-culture system, but sensitivity to ABT-199 (14 nm in SU-DHL-4, 32 nm in SU-DHL-8) in the co-culture system