Fig. 6

Ectopic expression of miR-30c or gain and loss of CTHRC1 affects GSK-3β/β-catenin signaling and Bax/Caspase-9/Caspase-3 signaling in breast cancer. a Protein levels of β-catenin, active β-catenin, normal and phosphorylated form of GSK-3β detected by western blot were shown in indicated cells. b Protein levels of Bax, Caspase-9 and Caspase-3 detected by western blot were shown in indicated cells. c Immunofluorescence staining of β-catenin in indicated cells. Original magnification: ×100. d Schematic representation of the major molecular mechanism that miR-30c/CTHRC1 axis exerts its role in cell proliferation, apoptosis, invasion and migration