Fig. 3

MiR-152-3p directly targets DNMT1. a MiR-152-3p was predicted to target REST. b Predicted DNMT1 3′ -UTR binding sites for miR-12-3p. Alignment of the seed regions of miR-152-3p with DNMT1 3′ UTR are shown. c MiR-152-3p directly targets DNMT1. A luciferase reporter vector containing either wild type (wt) or mutated (mut) DNMT1 3′-UTR was co-transfected with miR-152-3p precursor or scramble control in 293 cells, and the luciferase assay was performed. Mean and SEM of 3 independent MSC cultures are shown. **, P < 0.01 compared with control