Fig. 8

The PI3K/AKT signaling pathway regulates the process of glycolysis in hepatoma cells. a, b Effects of Girdin-shRNA, IGF-1, and Akti IV on glucose uptake, and lactate and ATP production, at 24 h after with different treatments in HepG2 (a) and Huh-7 cells (b). Mean ± SD (n = 3 independent experiments). *, P < 0.05, **, P < 0.01, and ***, P < 0.001. NC, normal control; Girdin-shRNA, shRNA transfected cells; IGF-1, insulin-like growth factor-1; Akti IV, Akt inhibitor IV