Fig. 9

Silencing Girdin increases the radiosensitivity of hepatoma cells in vivo. a Photograph of tumors derived from Girdin-shRNA transfected or untransfected HepG2 cells at the end of the observation period. Tumor tissues were irradiated or not at 2 weeks. b Tumor growth curve in nude mice. After tumor cells were injected subcutaneously into the right flank of the abdomen of nude mice, the short and long diameters of the tumors were measured every 3 days and tumor volumes (mm³) were calculated. Mean ± SD (n = 5/group). c Western blotting of Girdin, p-AKT, and HIF-1α protein expression in HepG2 xenografts.*, P < 0.05 and **, P < 0.01. NC, normal control; Girdin-shRNA, shRNA transfected cells; Ir, 10 Gy of X-rays