Fig. 4
MCC950 inhibits NLRP3 inflammasome-induced CSCs formation in Tgfbr1/Pten 2cKO mice. a Western blot analysis showed that the expression of NLRP3 inflammasome and CSCs makers BMI1, ALDH1 and CD44 were downregulated in the MCC950 treatment group than in the control group. b Immunohistochemical staining of NLRP3 inflammasome, BMI1, ALDH1 and CD44 in Tgfbr1/Pten conditional knockout mice after MCC950 treatment. Scale bars = 50 μm. c Quantitative analysis showed that the expression of NLRP3 inflammasome, BMI1, ALDH1 and CD44 was significantly reduced in the MCC950 treatment group than in the control group (Mean ± SEM, **P < 0.01; *P < 0.05)