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Table 2 Univariate and multivariate Cox proportional hazard models for overall survival (OS)

From: miR-19b-3p promotes colon cancer proliferation and oxaliplatin-based chemoresistance by targeting SMAD4: validation by bioinformatics and experimental analyses

 

Overall survival (OS)

Univariate

Multivariate

HR (95% CI)

P

HR (95% CI)

P

Age

  < 65 y

1

  ≥ 65 y

1.65 (0.93–2.27)

0.126

Gender

 Male

1

 Female

1.27 (0.83–2.01)

0.149

Location

 Left

1

 Others

0.82 (0.56–1.41)

0.632

T stage

 T1 + T2

1

 T3 + T4

1.72 (0.52–5.29)

0.391

N stage

 N0

1

1

 N1 + N2

6.71 (3.91–11.68)

<0.001*

0.35 (0.04–1.92)

0.163

AJCC stage

 II

1

1

 III

5.47 (4.25–10.27)

<0.001*

18.38 (2.93–152.17)

0.008*

Histologic grade

 Well Differentiated

1

1

 Poorly differentiated

3.42 (1.98–5.24)

<0.001*

2.34 (1.36–3.57)

0.316

Venous & Lymphatic invasion

 No

1

 Yes

0.75 (0.37–0.95) 0.271

Peritoneal Dissemination

 Absent

1

 Present

0.52 (0.24–0.82)

0.493

Liver Metastsis

 Negative

1

1

 Positive Multinodular

0.48 (0.29–0.81)

0.001*

0.59 (0.36–0.98) 0.024*

MiR-19b-3p

 Low

1

1

 High

2.79 (1.80–4.67)

<0.001*

2.23 (1.42–3.58)

0.008*

  1. HR: Hazard ratio; CI: Confidence interval
  2. *P < 0.05 was considered significant
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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