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Table 2 Univariate and multivariate Cox proportional hazard models for overall survival (OS)

From: miR-19b-3p promotes colon cancer proliferation and oxaliplatin-based chemoresistance by targeting SMAD4: validation by bioinformatics and experimental analyses

  Overall survival (OS)
Univariate Multivariate
HR (95% CI) P HR (95% CI) P
Age
  < 65 y 1
  ≥ 65 y 1.65 (0.93–2.27) 0.126
Gender
 Male 1
 Female 1.27 (0.83–2.01) 0.149
Location
 Left 1
 Others 0.82 (0.56–1.41) 0.632
T stage
 T1 + T2 1
 T3 + T4 1.72 (0.52–5.29) 0.391
N stage
 N0 1 1
 N1 + N2 6.71 (3.91–11.68) <0.001* 0.35 (0.04–1.92) 0.163
AJCC stage
 II 1 1
 III 5.47 (4.25–10.27) <0.001* 18.38 (2.93–152.17) 0.008*
Histologic grade
 Well Differentiated 1 1
 Poorly differentiated 3.42 (1.98–5.24) <0.001* 2.34 (1.36–3.57) 0.316
Venous & Lymphatic invasion
 No 1
 Yes 0.75 (0.37–0.95) 0.271
Peritoneal Dissemination
 Absent 1
 Present 0.52 (0.24–0.82) 0.493
Liver Metastsis
 Negative 1 1
 Positive Multinodular 0.48 (0.29–0.81) 0.001* 0.59 (0.36–0.98) 0.024*
MiR-19b-3p
 Low 1 1
 High 2.79 (1.80–4.67) <0.001* 2.23 (1.42–3.58) 0.008*
  1. HR: Hazard ratio; CI: Confidence interval
  2. *P < 0.05 was considered significant