Fig. 3

Upregulation of GOLPH3L conferred ovarian cancer to CDDP resistance in vivo. a The Kaplan-Meier survival curves compare ovarian cancer patients with low and high GOLPH3L expression levels. b GSEA plot, indicating a significant correlation between the mRNA levels of GOLPH3L expression in ovarian cancer and the CDDP resistance gene signatures in published datasets. c Representative tumor-bearing mice and tumor weights of the subcutaneous tumor model treated as indicated. d-e The luminescence of the intraperitoneal tumor xenografts from different treatment groups at the indicated weeks. f IHC staining demonstrated the expression of TUNEL-positive cells as well as active caspase 3 in the indicated tissues, * P < 0.05