Fig. 6

G-4 inactivates YAP in colorectal cancer cells. a Structure of G-4. b G-4 treatment (6 h, 10 μM) induces YAP phosphorylation in cytosol and decreases YAP levels in nucleus of HCT15/Tax cells. **p < 0.01 compared with control. c G-4 (6 h, 10 μM) decreases YAP nuclear localization in HCT15 /Tax cells. YAP subcellular localization was determined by immunofluorescence staining for endogenous YAP (green) along with DAPI for DNA (blue). Data are representative of at least three independent experiments. **p < 0.01 compared with control