Fig. 2

Upregulation of miR-141-3p inhibits bone metastasis of PC-3 cells in vivo. a Representative BLIs signal of bone metastasis of a mouse from the vector or miR-141-3p-overexpressing groups of mice at 12 mins and 8 week respectively. b Representative radiographic images of bone metastases in the indicated mice (arrows indicate osteolytic lesions).c Representative H&E-stained sections of tibias from the indicated mouse. d The sum of bone metastasis scores for each mouse in tumor-bearing mice inoculated with vector (n = 11) or miR-141-3p-overexpressing (n = 12) cells. e Quantification of the BLI signaling in the vector and miR-141-3p-overexpressing groups at 6, 7 and 8 weeks respectively. *P < 0.05. f and g Kaplan-Meyer analysis of mouse survival (f) and bone metastasis-free survival (g) in the vector and miR-141-3p-overexpressing groups