Fig. 5

LXA4 stable analog BML-111 suppresses liver metastasis of pancreatic cancer in vivo. a The liver metastatic model of BALB/c nude mice was established and treated with vehicle (methanol) or BML-111 (1 mg/kg) as interpreted in this figure (n = 6). b At the end of eighth week, the livers were obtained and the metastatic lesions (yellow arrow) were observed. c Liver indexes (liver weight/body weight, mg/g) were calculated. d and e Each liver was randomly sliced into 6 parts and made into paraffin-embedded sections. Each section was observed under microscope to calculate relative area of metastatic lesions. The final result was the average metastatic area in 6 parts. f Primary tumors in the spleen were stained immunohistochemically for TGF-β1 and Snail. *, P < 0.05