Fig. 6
From: Linc-ROR promotes esophageal squamous cell carcinoma progression through the derepression of SOX9
Targeting linc-ROR represses tumor growth and SOX9 expression in ESCC xenografts. a Experimental design for the linc-ROR targeted therapy using cholesterol-conjugated siRNA. b Tumors were excised from mice at the end of the experiment. c, d Tumor volume (c) and weight (d) were calculated as described in Materials and methods. e Representative immunohistochemistry staining of SOX9, CD44 and vimentin in ESCC xenografts after siRNA treatment. Scale bars, 1 mm (left) and 50 μm (right). f Proposed model for the role of the linc-ROR–miRNA–SOX9 regulatory network to promote ESCC progression