Fig. 2

Notch1 function in tumor growth depended on the immune system. a Tumor growth curve of shNotch1 and shCon cells in BALB/c Nude mice. b Tumor growth curve of Notch1 and GFP cells in BALB/c Nude mice. c Tumor volume of shNotch1 and shCon cells on day 28 in C57 BL/6 mice with or without depletion of CD8⁺ or CD4⁺ T cells, or NK cells. 8 mice per group were used in this experiment. *, P < 0.05. “ns”, no statistical significance