Fig. 6

ONC201 and VEGF inhibitors act synergistically to impact apoptosis, growth arrest, and migration. a M30 expression from M30-apoptosense ELISA taken at week 3 in HCT116 xenograft-bearing athymic nude mice. N = 5. b Representative image and (c) quantification of Ki67+ cells in HT29 xenografts of ONC201, bevacizumab, and ONC201 + bevacizumab in combination. N = 20 slides, 5 per tumor. d Migration assay using xCelligence of HUVECS migrating to FBS + VEGF with +/− ONC201 treatment in upper chamber and +/− bevacizumab in lower chamber. N = 4