Fig. 6

miR-181 targets CTDSPL, which modulates the cell cycle effector E2F1. Schematic representation of the pathway modulated by miR-181 in UM cells progressing through the cell cycle. miR-181 overexpression in UM cells induces progression through the G1/S transition and promotes S-phase entry. Thus, miR-181 induces cell cycle progression by repressing the downstream target CTDSPL, which in turn results in the phosphorylation of RB and an accumulation of the downstream cell cycle effector E2F1