Fig. 4

Downregulation of TFAP2C improves chemosensitivity of CRC cells to 5-FU in vivo. a Representative images of the tumors are shown in the xenograft model of nude mice. b After one weeks of inoculating HCT116 cells, mice were intraperitoneal injected with 50 mg/kg 5-FU per day for four weeks. Tumor volumes in the indicated groups were measured from the fifth day at five days interval. Data presented are the mean ± s.d. c Tumor weights of each group. d Analysis of the activities of caspase-3 and caspase-9 were examined in the indicated tumor from mice. Error bars represent the mean ± S.D. of three independent experiments. *P < 0.05