Fig. 6

Inhibitors of FAK and ERK1/2 impair the migration and growth of NPC cells induced by CLCA2 silencing. a-b Cells were treated with 1 μM PF-573228, 2 μM U0126 or DMSO for 24 h, and subjected to migration, representative images and quantification of PF-573228 and U0126 attenuate the effects of CLCA2 silencing on the migratory abilities of S26 and SUNE-1 cells as determined by migration assays. Columns, average of three independent experiments; bars, SD. *P < 0.05, **P < 0.01, Student t test. c Cells were treated with 2 μM U0126 or DMSO for 24 h, and subjected to and MTS assays. U0126 attenuate the acceleratedly effects of CLCA2 silencing on the growth abilities of S26 cells as determined by MTS assays. The difference is statistically significant in control and drug groups. d Cells were treated with 1 μM PF-573228 or DMSO for 24 h, and subjected to and MTS assays. Treatment with PF-573228 has no influence the effects of CLCA2 silencing on the growth abilities of S26 cells as determined by MTS assays. The difference between control and drug groups has no statistical significance