Fig. 7

Schematic model of the proposed mechanisms for the antitumor activity of triptolide in HCC cells. Besides regulating a couple of signaling molecules, such as p53, Bcl-2, and Akt, triptolide inhibited the expression of miR-17-92 and miR-106b-25 through repressing c-Myc, resulting in up-regulation of their common target genes and subsequent cell death in HCC cells