Fig. 6

The tissue distributions of PTX in tumor tissues in different drug groups. Notes: The PTX levels in tumor tissues at various time points after drug delivery by three kinds of PTX solutions. (a) The PTX concentration of three groups in tumor tissues; (b) The PTX concentration in tumor tissues at 6 h. The PTX concentrations at various time points were much higher in the PTX-PEG-PLA-FA-NP group than free PTX and FA-free nano-carriers group, which suggested that the PTX-PEG-PLA-FA-NP could accumulate selectively in tumor tissues. For example, the PTX level in the PTX-PEG-PLA-FA-NP group at 6 h (15.267 ± 0.475 μg/ml) was much higher than that of PTX-PEG-PLA-NP group (5.883 ± 0.674 μg/ml) and PTX group (4.663 ± 0.357 μg/ml) (p < 0.05). *p < 0.05, **p < 0.01, ***p < 0.001